6-chloro-4-phenylquinolin-2(1H)-one synthesis

8synthesis methods

Product Name:6-chloro-4-phenylquinolin-2(1H)-one
CAS Number:30169-33-6
Molecular formula:C15H10ClNO
Molecular Weight:255.7

719-59-5 Synthesis

719-59-5
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141-78-6 Synthesis

141-78-6
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30169-33-6
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Yield:30169-33-6 96%

Reaction Conditions:

Stage #1: 5-chloro-2-aminobenzophenone;ethyl acetatewith lithium hexamethyldisilazane in tetrahydrofuran at 0 - 20; for 1 h;Knoevenagel condensation;
Stage #2: with water in tetrahydrofuran at 25; for 2 h;

References:

Wang, Jianji;Discordia, Robert P.;Crispino, Gerard A.;Li, Jun;Grosso, John A.;Polniaszek, Richard;Truc, Vu C. [Tetrahedron Letters,2003,vol. 44,# 22,p. 4271 - 4273]

32315-10-9 Synthesis