6-Chloro-5-methyl-nicotinic acid ethyl ester synthesis

5synthesis methods

Product Name:6-Chloro-5-methyl-nicotinic acid ethyl ester
CAS Number:942511-70-8
Molecular formula:C9H10ClNO2
Molecular Weight:199.63

85614-89-7 Synthesis

Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

85614-89-7
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6-Chloro-5-methyl-nicotinic acid ethyl ester

942511-70-8
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$124.00/500mg

Yield:942511-70-8 85%

Reaction Conditions:

with trichlorophosphate at 120; for 1.5 h;

Steps:

9.1.iii

iii) 6-Chloro-5-methyl-nicotinic acid ethyl ester A mixture of θ-hydroxy-S-methyl-nicotinic acid ethyl ester (1.65 g, 9.11 mmol) in POCI₃ (2.55 ml_, 27.3 mmol) was stirred at 120⁰C for 1.5 hour. The mixture was cooled down and poured into ice. The resulting precipitate was filtered off, washed with water and then solubilised in DCM. The organic phase was dried over sodium sulfate and then concentrated in vacuo to afford 6-chloro-5-methyl-nicotinic acid ethyl ester (1.55 g, 85%) as a dark brown solid. (ES- MS: m/z 241.1/243.1 [M+CH₃CN+H] t_R 5.12 min (system 2)).

References:

WO2007/71358,2007,A1 Location in patent:Page/Page column 59-60

64-17-5 Synthesis