(6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID synthesis

2synthesis methods

Product Name:(6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID
CAS Number:59128-13-1
Molecular formula:C9H7ClN2O2
Molecular Weight:210.62

59128-02-8 Synthesis

IMidazo[1,2-a]pyridine-2-acetic acid, 6-chloro-, ethyl ester

59128-02-8
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$52.10/250mg

(6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID

59128-13-1
40 suppliers
$80.00/50mg

Yield:59128-13-1 79%

Reaction Conditions:

with lithium hydroxide monohydrate;sodium hydroxide in tetrahydrofuran at 20; for 3 h;

Steps:

31.B Step B:

Step B: To a solution of ethyl 2-(6-chloroimidazo[l,2-a]pyridin-2-yl)acetate (2.38 g, 10 mmol) in THF was added aqueous NaOH (3 N, 6.6 mL, 20 mmol). After stirring at room temperature for 3 h, the mixture was concentrated. The residual mixture was acidified with aqueous HC1 (6 N) to pH 3. A precipitate formed. The precipitate was collected by vacuum filtration, washed with water and dried, yielding 2-(6-chloroimidazo[l,2-a]pyridin-2-yl)acetic acid (1.66 g, 79%) as a white solid. MS m/z 211.1 [M+H]⁺.

References:

WO2013/101974,2013,A1 Location in patent:Paragraph 00763; 00765

1072-98-6
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$5.00/1g

59128-13-1
40 suppliers
$80.00/50mg

References