ChemicalBook CAS DataBase List 6-Chloropurine ribonucleoside

6-Chloropurine ribonucleoside synthesis

8synthesis methods

Product Name:6-Chloropurine ribonucleoside
CAS Number:2004-06-0
Molecular formula:C10H11ClN4O4
Molecular Weight:286.67

5987-73-5 Synthesis

2,3,5-TRI-O-ACETYL-6-CHLOROPURINE-9--D-RIBOFURANOSIDE

5987-73-5
60 suppliers
$42.00/100mg

2004-06-0
206 suppliers
$8.00/1g

Yield:2004-06-0 86.4%

Reaction Conditions:

with sodium methylate in methanol

Steps:

8 6-chloro-9-β-D-ribofuranosyl-9H-purine STR15
EXAMPLE 8 6-chloro-9-β-D-ribofuranosyl-9H-purine STR15 532 g of the product of Example 7 are dissolved in 2.43 L of dry methanol. The solution is cooled at about -11° C. and 13.2 g of sodium methoxide are added under stirring. When the addition is complete the stirring is continued for minimum 1 hour. The temperature is raised to 20° C.-25° C. for minimum 2 hours. The precipitate is filtered and rinsed with methanol to afford 304.6 g of crude product. Yield: 86.4%.

References:

G. D. Searle & Co. US4992535, 1991, A

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