![](/CAS/GIF/2004-06-0.gif)
6-Chloropurine ribonucleoside synthesis
- Product Name:6-Chloropurine ribonucleoside
- CAS Number:2004-06-0
- Molecular formula:C10H11ClN4O4
- Molecular Weight:286.67
![2,3,5-TRI-O-ACETYL-6-CHLOROPURINE-9--D-RIBOFURANOSIDE](/CAS/GIF/5987-73-5.gif)
5987-73-5
60 suppliers
$42.00/100mg
![6-Chloropurine ribonucleoside](/CAS/GIF/2004-06-0.gif)
2004-06-0
206 suppliers
$8.00/1g
Yield:2004-06-0 86.4%
Reaction Conditions:
with sodium methylate in methanol
Steps:
8 6-chloro-9-β-D-ribofuranosyl-9H-purine STR15
EXAMPLE 8 6-chloro-9-β-D-ribofuranosyl-9H-purine STR15 532 g of the product of Example 7 are dissolved in 2.43 L of dry methanol. The solution is cooled at about -11° C. and 13.2 g of sodium methoxide are added under stirring. When the addition is complete the stirring is continued for minimum 1 hour. The temperature is raised to 20° C.-25° C. for minimum 2 hours. The precipitate is filtered and rinsed with methanol to afford 304.6 g of crude product. Yield: 86.4%.
References:
G. D. Searle & Co. US4992535, 1991, A
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3510-73-4
2 suppliers
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![6-Chloropurine ribonucleoside](/CAS/GIF/2004-06-0.gif)
2004-06-0
206 suppliers
$8.00/1g
![Inosine](/CAS/GIF/58-63-9.gif)
58-63-9
625 suppliers
$5.00/25g
![6-Chloropurine ribonucleoside](/CAS/GIF/2004-06-0.gif)
2004-06-0
206 suppliers
$8.00/1g
![2',3',5'-Tri-O-acetylinosine](/CAS/GIF/3181-38-2.gif)
3181-38-2
167 suppliers
$5.00/250mg
![6-Chloropurine ribonucleoside](/CAS/GIF/2004-06-0.gif)
2004-06-0
206 suppliers
$8.00/1g