2-Chloroadenosine synthesis
- Product Name:2-Chloroadenosine
- CAS Number:146-77-0
- Molecular formula:C10H12ClN5O4
- Molecular Weight:301.69
Yield:146-77-0 85%
Reaction Conditions:
with hydrogenchloride;potassium dihydrogenphosphate;potassium hydroxide in water;dimethyl sulfoxide; pH=7.1-7.2 at 58 - 61; for 4 h;Enzymatic reaction;
Steps:
1a Preparation of 2-chloroadenosine (III) from 2-chloroadenine and uridine
400 g of uridine and 150 g of KH2PO4 were dissolved with stirring in a mixture of water (52 l) and DMSO (1.8 l) at 58-61° C.
To the resulting solution, a first portion (0.75 l) of a solution prepared from 2-chloroadenine (85 g), water (7 l), and KOH (120 g) was added.
The pH of the resulting mixture was adjusted to 7.1-7.2 with aqueous KOH solution.
References:
SYNBIAS PHARMA AG;ZABUDKIN, Alexander;MATVIENKO, Victor;MATVIIENKO, Iaroslav;SYPCHENKO, Volodymyr US2017/44204, 2017, A1 Location in patent:Paragraph 0056
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