6-Desmethyl Papaverine synthesis
- Product Name:6-Desmethyl Papaverine
- CAS Number:18813-63-3
- Molecular formula:C19H19NO4
- Molecular Weight:325.36
![Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, 2-oxide](/CAS/20180601/GIF/33520-96-6.gif)
Yield:18813-63-3 7 mg ，33520-96-6 30 mg
Reaction Conditions:
with dipotassium hydrogenphosphate;D-glucose;sodium chloride in water;acetone;Microbiological reaction;
Steps:
General procedure: Papaverine (600 mg) dissolved in acetone and then equally divided among 2 L flasks containing 400 ml of stage II culture in a concentration of 10 mg/50 ml culture media (w/v). All fermentation experiments utilized a liquid media of the following composition: 20 g dextrose, 5 g yeast extract, 5 g K2HPO4, 5 g peptone and 5 g NaCl in 1 L of distilled water, which was sterilized at 121 °C for 15 min. After maximum conversion, the experiments were terminated and rendered alkaline with conc. Ammonium hydroxide (1 ml/30 ml culture, pH 8) then exhaustively extracted with equal volume of ethyl acetate, filtered off by a cheese cloth over anhydrous Na2SO4 and evaporated to dryness under vacuum using rotary evaporator to give fermentation residues.
References:
Eliwa, Duaa;Albadry, Mohamed A.;Ibrahim, Abdel-Rahim S.;Kabbash, Amal;Meepagala, Kumudini;Khan, Ikhlas A.;El-Aasr, Mona;Ross, Samir A. [Phytochemistry,2021,vol. 183,art. no. 112598]
58-74-2
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18813-63-3
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