![](/CAS/GIF/22245-98-3.gif)
6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE synthesis
- Product Name:6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE
- CAS Number:22245-98-3
- Molecular formula:C9H9NO2
- Molecular Weight:163.17
![5-Hydroxy-1-indanone](/CAS/GIF/3470-49-3.gif)
3470-49-3
163 suppliers
$10.00/1g
![6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE](/CAS/GIF/22245-98-3.gif)
22245-98-3
82 suppliers
$27.00/100mg
Yield: 98%
Reaction Conditions:
with sodium azide;trifluoroacetic acid for 2 h;Heating / reflux;
Steps:
11.1
To a solution of 5-hydroxyindanone (1.5 g, 10 mmol) in 15 ml trifluroracetic acid was added sodium azide (1.0 g, 15 mmol) portionwise. The solution was stirred at reflux for 2 h, then cooled and diluted with water. The volatiles were removed in vacuo and the resulting residue diluted with saturated NaHCO3 and extracted with ethyl acetate. The organic layers were dried over MgSO4 and concentrated to yield 11-1 (1.6 g, 98%) as a tan solid which was used without further purification.
References:
Pharmacopeia, Inc. US2005/222203, 2005, A1 Location in patent:Page/Page column 19-20
![6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE](/CAS/GIF/22246-12-4.gif)
22246-12-4
115 suppliers
$45.00/50mg
![6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE](/CAS/GIF/22245-98-3.gif)
22245-98-3
82 suppliers
$27.00/100mg
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2039-67-0
238 suppliers
$17.46/5G
![6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE](/CAS/GIF/22245-98-3.gif)
22245-98-3
82 suppliers
$27.00/100mg
![5-Hydroxy-1-indanone](/CAS/GIF/3470-49-3.gif)
3470-49-3
163 suppliers
$10.00/1g
![Trichloroacetic acid](/CAS/GIF/76-03-9.gif)
76-03-9
413 suppliers
$14.00/25g
![6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE](/CAS/GIF/22245-98-3.gif)
22245-98-3
82 suppliers
$27.00/100mg
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33543-63-4
9 suppliers
inquiry
![6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE](/CAS/GIF/22245-98-3.gif)
22245-98-3
82 suppliers
$27.00/100mg