![](/CAS/GIF/75433-99-7.gif)
6-METHOXY-QUINOLINE-2-CARBOXYLIC ACID synthesis
- Product Name:6-METHOXY-QUINOLINE-2-CARBOXYLIC ACID
- CAS Number:75433-99-7
- Molecular formula:C11H9NO3
- Molecular Weight:203.19
![6-METHOXY-QUINOLINE-2-CARBALDEHYDE](/CAS/GIF/89060-22-0.gif)
89060-22-0
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![6-METHOXY-QUINOLINE-2-CARBOXYLIC ACID](/CAS/GIF/75433-99-7.gif)
75433-99-7
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Yield:75433-99-7 100%
Reaction Conditions:
with sodium chlorite;sodium dihydrogenphosphate in water;tert-butyl alcohol at 20; for 2 h;
Steps:
3 6-methoxyquinoline-2-carboxylic acid (Compound 4)
A solution of 6-methoxyquinoline-2-carboaldehyde (Compound 3) (0.8 g, 4.27 mmol) dissolved in tert-butanol (20 mL) was carefully added dropwise to a solution of sodium dihydrogen phosphate (NaH2PO4; 4.10 g, 34.2 mmol) and sodium chlorite (NaClO2, 3.87 g, 42.7 mmol) in water (10 mL), followed by allowing to react at room temperature for 2 hours. The reaction mixture was adjusted to a pH of 4 and extracted with ethyl acetate (3×20 mL), the organic layer was dried over sodium sulfate (Na2SO4), and the desiccant was removed by filtration. Thereafter, the filtrate was concentrated under reduced pressure, and the obtained product, Compound 4 (865 mg, 100%) was used in the following Reference Example 4 reaction without purification.
References:
US2021/255203,2021,A1 Location in patent:Paragraph 0167-0168
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75433-99-7
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$150.00/250mg
![2-Quinolinecarboxylic acid, 6-methoxy-, sodium salt (1:1)](/CAS/20211123/GIF/111498-57-8.gif)
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![6-METHOXY-QUINOLINE-2-CARBOXYLIC ACID](/CAS/GIF/75433-99-7.gif)
75433-99-7
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$150.00/250mg
![1-benzoyl-6-methoxy-2H-quinoline-2-carbonitrile](/CAS/GIF/6334-31-2.gif)
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75433-99-7
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$150.00/250mg
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100393-79-1
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![6-METHOXY-QUINOLINE-2-CARBOXYLIC ACID](/CAS/GIF/75433-99-7.gif)
75433-99-7
47 suppliers
$150.00/250mg