(6-(Methoxymethyl)pyridin-2-yl)methanol synthesis

7synthesis methods

Product Name:(6-(Methoxymethyl)pyridin-2-yl)methanol
CAS Number:136133-18-1
Molecular formula:C8H11NO2
Molecular Weight:153.18

890904-66-2 Synthesis

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136133-18-1
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Yield:136133-18-1 70.4%

Reaction Conditions:

with methanol;sodium tetrahydridoborate at 0 - 20; for 2 h;

Steps:

26.1 Step-1 : (6-(methoxymethyl)pyridin-2-yl)methanol

To a solution of 6-(methoxymethyl)pyridine-2-carbaldehyde (450.00 mg, 2.977 mmol) in MeOH (10.00 mL) was added NaBT (112.6 mg, 2.977 mmol) in portions at 0 °C. The resulting mixture was stirred at room temperature for 2 h. The reaction mixture was then quenched by the addition of water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to afford (6- (methoxymethyl)pyridin-2-yl)methanol (338 mg, 70.4%) as a yellow oil. MS (ESI) calc’d for (C₇H₈C1NO) (M+l)⁺, 154.1, found 154.1.

References:

WO2022/118210,2022,A1 Location in patent:Page/Page column 146-147

1195-59-1 Synthesis