6-Methoxypyrido[3,2-b]pyrazin-3(4H)-one synthesis

8synthesis methods

Product Name:6-Methoxypyrido[3,2-b]pyrazin-3(4H)-one
CAS Number:917344-37-7
Molecular formula:C8H7N3O2
Molecular Weight:177.16

1073633-84-7 Synthesis

1,4-dihydro-6-Methoxy-Pyrido[2,3-b]pyrazin-3(2H)-one

1073633-84-7
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917344-37-7
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Yield:917344-37-7 68%

Reaction Conditions:

with manganese(IV) oxide in N,N-dimethyl-formamide at 20 - 50; for 5 h;

Steps:

A.e

(e) 6-(Methyloxy)pyrido[2,3-b]pyrazin-3(4H)-oneA solution of 6-(methyloxy)-l,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one (10.9g, 61 mmol) in DMF (200ml) was treated with MnC>2 (26.4g). After 2 hours at room temperature no reaction had occured so more MnC>2 (18g) was added and the mixture heated at 5O⁰C for 3 hours. The reaction mixture was filtered through Celite, washing with warm DMF (2 x 100ml). The collected solution was concentrated to ca 100ml, whereupon precipitation of the product commenced. Diluting slowly with water (200ml) and then filtering the precipitate which was dried in vacuo gave the product as a light brown solid (7.3g, 68%).

References:

WO2009/87153,2009,A1 Location in patent:Page/Page column 49