ChemicalBook CAS DataBase List 6-Methylindole

6-Methylindole synthesis

6synthesis methods

Product Name:6-Methylindole
CAS Number:3420-02-8
Molecular formula:C9H9N
Molecular Weight:131.17

1670-82-2
344 suppliers
$10.00/1g

3420-02-8
242 suppliers
$10.00/1g

Yield:-

Reaction Conditions:

with thionyl chloride in ethanol for 3 h;Reflux;

Steps:

ethyl 1H-indole-6-carboxylate (19a)
A solution of 1H-indole-6-carboxylic acid (0.5 g, 0.3 mmol) in EtOH (15 mL), then SOCl₂ (0.22 mL, 3 mmol)was added dropwise into the solution at 0 °C and refluxed for 3 h. The solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate (50 mL) and then washed with saturated NaHCO₃ solution, finally washed with water and dried over anhydrous Na₂SO₄. The solvent was removed under vacuum to get carboxylic acid ester. The ester obtained was taken as such in the next step of synthesis. LC-MS m/z: 162.2 [M+H]⁺.

References:

Luan, Shenglin;Ge, Qi;Chen, Yedong;Dai, Mingyang;Yang, Jinyu;Li, Kun;Liu, Dan;Zhao, Linxiang [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 9,p. 1943 - 1948] Location in patent:supporting information