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ethyl 4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylate synthesis

1synthesis methods
-

Yield:-

Reaction Conditions:

with sodium ethanolate in ethanol; for 28 h;Reflux;Inert atmosphere;

References:

Debenham, John S.;Madsen-Duggan, Christina;Clements, Matthew J.;Walsh, Thomas F.;Kuethe, Jeffrey T.;Reibarkh, Mikhail;Salowe, Scott P.;Sonatore, Lisa M.;Hajdu, Richard;Milligan, James A.;Visco, Denise M.;Zhou, Dan;Lingham, Russell B.;Stickens, Dominique;Demartino, Julie A.;Tong, Xinchun;Wolff, Michael;Pang, Jianmei;Miller, Randy R.;Sherer, Edward C.;Hale, Jeffrey J. [Journal of Medicinal Chemistry,2016,vol. 59,# 24,p. 11039 - 11049]

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