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2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID synthesis

1synthesis methods
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Yield:60712-47-2 160 mg

Reaction Conditions:

Stage #1: (R)-phenylglycine;p-toluenesulfonyl chloridewith sodium hydroxide in water;acetonitrile; for 1 h;
Stage #2: with hydrogenchloride in water;ethyl acetate;acetonitrile; for 0.0833333 h;

References:

Pant, Shishir M.;Mukonoweshuro, Amanda;Desai, Bimbisar;Ramjee, Manoj K.;Selway, Christopher N.;Tarver, Gary J.;Wright, Adrian G.;Birchall, Kristian;Chapman, Timothy M.;Tervonen, Topi A.;Klefstr?m, Juha [Journal of Medicinal Chemistry,2018,vol. 61,# 10,p. 4335 - 4347] Location in patent:supporting information

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