(2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine synthesis

13synthesis methods

Product Name:(2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine
CAS Number:656241-17-7
Molecular formula:C26H42N2O5
Molecular Weight:462.62

109838-85-9 Synthesis

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

109838-85-9
179 suppliers
$40.00/500mg

172900-69-5 Synthesis

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene

172900-69-5
80 suppliers
$33.00/250mg

(2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine

656241-17-7
7 suppliers
$115.00/5mg

Yield:656241-17-7 91%

Reaction Conditions:

Stage #1: (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazinewith n-butyllithium in hexane at -75; for 0.5 h;
Stage #2: (R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene in tetrahydrofuran at -75 - -20; for 20 h;

References:

Goeschke, Richard;Stutz, Stefan;Heinzelmann, Walter;Maibaum, Juergen [Helvetica Chimica Acta,2003,vol. 86,# 8,p. 2848 - 2870]

900811-38-3 Synthesis