6-Benzimidazolecarboxylicacid,1,2-dimethyl-(7CI,8CI) synthesis

4synthesis methods

Product Name:6-Benzimidazolecarboxylicacid,1,2-dimethyl-(7CI,8CI)
CAS Number:6595-00-2
Molecular formula:C10H10N2O2
Molecular Weight:190.2

Methyl 1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate

1038387-93-7
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6-Benzimidazolecarboxylicacid,1,2-dimethyl-(7CI,8CI)

6595-00-2
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Yield:6595-00-2 82.36%

Reaction Conditions:

with water;potassium hydroxide in methanol at 60; for 3 h;

Steps:

General method of synthesis of 1-Methyl-1H-benzimidazole-6-carboxylic Acids (31-40)

General procedure: A solution of the adequate ester 20-30 in MeOH and 30% KOH was stirred at 60 °C for 3 h. The solution was cooled, diluted with water and acidified to pH 4 with 20% HCl solution. The suspension was filtered and purified as needed to give the corresponding acid.

References:

Soria-Arteche, Olivia;Hernandez-Campos, Alicia;Yepez-Mulia, Lilian;Trejo-Soto, Pedro Josue;Hernandez-Luis, Francisco;Gres-Molina, Jorge;Maldonado, Luis A.;Castillo, Rafael [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 24,p. 6838 - 6841] Location in patent:supporting information

Benzoic acid, 3-(methylamino)-4-nitro-, methyl ester (9CI)

251643-13-7
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$92.76/0.5g

6595-00-2
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References

616224-38-5 Synthesis

616224-38-5
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6595-00-2
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6-broMo-1,2-diMethyl-1H-1,3-benzodiazole

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6595-00-2
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References