![](/CAS/GIF/666816-98-4.gif)
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione synthesis
- Product Name:8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
- CAS Number:666816-98-4
- Molecular formula:C10H9BrN4O2
- Molecular Weight:297.11
![8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione](/NewsImg/2023-11-29/6383684839403740088632397.jpg)
![8-Bromo-3-methyl-xanthine](/CAS/GIF/93703-24-3.gif)
93703-24-3
389 suppliers
$30.00/1g
![1-BROMO-2-BUTYNE](/CAS/GIF/3355-28-0.gif)
3355-28-0
366 suppliers
$6.00/1g
![8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione](/CAS/GIF/666816-98-4.gif)
666816-98-4
389 suppliers
$19.00/1g
Yield:666816-98-4 98%
Reaction Conditions:
with sodium carbonate in acetone at 40; for 4 h;Temperature;Reagent/catalyst;Solvent;
Steps:
7-9 Example 7: Preparation of Compound IV
Compound III (2.450 g, 10 mmol),1-bromo-2-butyne (1.596 g, 12 mmol),Sodium carbonate (1.590 g, 15 mmol),20mL of acetone was then added to a 100mL flask, the reaction system was heated to 40 ° C, and the reaction was stirred for 4h.After the reaction was cooled to room temperature, suction filtration was performed, and the filter cake was washed with methanol to obtain a crude product as a pale yellow solid.The crude product was reconstituted with dichloromethane and cyclohexane.Yield 2.912 g of compound IV,The yield was 98% and the purity was 99.9%.
References:
CN110563728,2019,A Location in patent:Paragraph 0052-0058
![3-Methylxanthine](/CAS/GIF/1076-22-8.gif)
1076-22-8
455 suppliers
$15.00/5g
![8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione](/CAS/GIF/666816-98-4.gif)
666816-98-4
389 suppliers
$19.00/1g
![5,6-Diamino-1-methyluracil](/CAS/GIF/6972-82-3.gif)
6972-82-3
128 suppliers
$21.00/100mg
![8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione](/CAS/GIF/666816-98-4.gif)
666816-98-4
389 suppliers
$19.00/1g
![6-Amino-1-methyluracil](/CAS/GIF/2434-53-9.gif)
2434-53-9
237 suppliers
$6.00/5g
![8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione](/CAS/GIF/666816-98-4.gif)
666816-98-4
389 suppliers
$19.00/1g
![6-AMINO-1-METHYL-5-NITROSOURACIL](/CAS/GIF/6972-78-7.gif)
6972-78-7
97 suppliers
$42.00/5g
![8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione](/CAS/GIF/666816-98-4.gif)
666816-98-4
389 suppliers
$19.00/1g