ChemicalBook CAS DataBase List 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione synthesis

6synthesis methods

Product Name:8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
CAS Number:666816-98-4
Molecular formula:C10H9BrN4O2
Molecular Weight:297.11

8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione (2.450 g, 10 mmol),1-bromo-2-butyne (1.596 g, 12 mmol), Sodium carbonate (1.590 g, 15 mmol), and 20mL of acetone was added to a 100mL flask. The reaction system was heated to 40 ° C, and the reaction was stirred for 4h. After the reaction was cooled to room temperature, suction filtration was performed, and the filter cake was washed with methanol to obtain a crude product as a pale yellow solid. The crude product was reconstituted with dichloromethane and cyclohexane. Yield 2.912 g of 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione. The yield was 98%, and the purity was 99.9%.

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

93703-24-3
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$30.00/1g

3355-28-0 Synthesis

3355-28-0
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666816-98-4
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$19.00/1g

Yield:666816-98-4 98%

Reaction Conditions:

with sodium carbonate in acetone at 40; for 4 h;Temperature;Reagent/catalyst;Solvent;

Steps:

7-9 Example 7: Preparation of Compound IV

Compound III (2.450 g, 10 mmol),1-bromo-2-butyne (1.596 g, 12 mmol),Sodium carbonate (1.590 g, 15 mmol),20mL of acetone was then added to a 100mL flask, the reaction system was heated to 40 ° C, and the reaction was stirred for 4h.After the reaction was cooled to room temperature, suction filtration was performed, and the filter cake was washed with methanol to obtain a crude product as a pale yellow solid.The crude product was reconstituted with dichloromethane and cyclohexane.Yield 2.912 g of compound IV,The yield was 98% and the purity was 99.9%.

References:

CN110563728,2019,A Location in patent:Paragraph 0052-0058

1076-22-8 Synthesis