Butanethioic acid, 3-hydroxy-, S-[2-(acetylamino)ethyl] ester, (3R)- synthesis

3synthesis methods

Product Name:Butanethioic acid, 3-hydroxy-, S-[2-(acetylamino)ethyl] ester, (3R)-
CAS Number:67024-17-3
Molecular formula:C8H15NO3S
Molecular Weight:205.27

1190-73-4
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$18.00/1g

(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT

13613-65-5
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$5.00/250mg

Butanethioic acid, 3-hydroxy-, S-[2-(acetylamino)ethyl] ester, (3R)-

67024-17-3
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Yield:67024-17-3 12%

Reaction Conditions:

Stage #1: sodium (R)-3-hydroxybutyratewith trifluorormethanesulfonic acid in dichloromethane at 0; for 1 h;
Stage #2: 2-(acetylamino)ethanethiolwith dmap;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane at 22; for 16 h;

References:

Liu, Yating;Su, Li;Fang, Qing;Tabudravu, Jioji;Yang, Xiaohui;Rickaby, Kirstie;Trembleau, Laurent;Kyeremeh, Kwaku;Deng, Zixin;Deng, Hai;Yu, Yi [Journal of Organic Chemistry,2019,vol. 84,# 24,p. 16323 - 16328] Location in patent:supporting information

625-72-9 Synthesis

625-72-9
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$36.00/100mg

1190-73-4
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$18.00/1g

67024-17-3
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References

23255-41-6 Synthesis

S-[2-(acetylamino)ethyl] 3-oxobutanethioate

23255-41-6
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67024-17-3
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References