Z-2-(2,3-Dichlorophenyl)methylene-3-oxobutanoic acid methyleater synthesis
- Product Name:Z-2-(2,3-Dichlorophenyl)methylene-3-oxobutanoic acid methyleater
- CAS Number:68064-69-7
- Molecular formula:C12H10Cl2O3
- Molecular Weight:273.11
Yield:68064-69-7 80%
Reaction Conditions:
piperidine;2-Picolinic acid in isopropyl alcohol at 40 - 45; for 6 h;
Steps:
1. I Example 1; Preparation of Felodipine; Step I
To a solution of 2,3-dichlorobenzaldehyde (101.0 g, 0.58 mol) in isopropanol (450 mL) is added picolinic acid (3.5 g, 29 mmol), piperidine (2.4 g, 29 mmol) and methyl acetoacetate (86.3 g, 0.74 mol). The solution is stirred at 4045 C. for 6 h, cooled to room temperature and the solid is filtered and washed with isopropanol. The damp cake is dried to yield 125.9 g (80%) benzylidene 4a as white solid.
References:
US2004/204604,2004,A1 Location in patent:Page 4-5; 1
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