ChemicalBook CAS DataBase List 1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine

1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine synthesis

1synthesis methods

Product Name:1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine
CAS Number:681482-80-4
Molecular formula:C23H26F3NO4
Molecular Weight:437.45

36603-49-3
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287952-67-4 Synthesis

4-[4-(TRIFLUOROMETHOXY)PHENOXY]PIPERIDINE

287952-67-4
104 suppliers
$13.00/250mg

1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine

681482-80-4
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Yield:681482-80-4 64%

Reaction Conditions:

with caesium carbonate;palladium diacetate;2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl in toluene; for 0.5 h;Heating;

References:

Sasaki, Hirofumi;Haraguchi, Yoshikazu;Itotani, Motohiro;Kuroda, Hideaki;Hashizume, Hiroyuki;Tomishige, Tatsuo;Kawasaki, Masanori;Matsumoto, Makoto;Komatsu, Makoto;Tsubouchi, Hidetsugu [Journal of Medicinal Chemistry,2006,vol. 49,# 26,p. 7854 - 7860]