6-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester synthesis

7synthesis methods

Product Name:6-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester
CAS Number:68882-86-0
Molecular formula:C11H9NO3
Molecular Weight:203.19

38896-30-9 Synthesis

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6-Quinolinecarboxylic acid, 1,2-dihydro-2-oxo-, Methyl ester

68882-86-0
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Yield:68882-86-0 92%

Reaction Conditions:

with water;chloroacetic acid ethyl ester in ethyl acetate; for 0.5 h;Microwave irradiation;

Steps:

13 Example 13: 2-oxo-1,2-dihydroquinolin-6-carboxylic acid Methyl ester

In a 50mL pressure-resistant reaction tube, Then added 1.87 g of quinoline-6-formic acid methyl ester, Ethyl chloroacetate 1.23g, Distilled water 0.54g, 20 ml of ethyl acetate, The resulting mixture was subjected to microwave irradiation for 30 minutes in a 300 W microwave stirring reaction apparatus. Washing the reaction solution with hot water, Liquid separation, Collect organic phase, Ethyl acetate and ethyl chloroacetate were removed under reduced pressure. Recrystallization 2-oxo-1,2-dihydroquinolin-6-carboxylic acid Methyl ester 1.86g, The yield was 92%.

References:

CN108503582,2018,A Location in patent:Paragraph 0085; 0086