7-Benzofurancarboxylic acid, 2,3-dihydro-3-oxo- synthesis

6synthesis methods

Product Name:7-Benzofurancarboxylic acid, 2,3-dihydro-3-oxo-
CAS Number:1344897-22-8
Molecular formula:C9H6O4
Molecular Weight:178.14

7-Benzofurancarboxylic acid, 3-(acetyloxy)-

1616110-79-2
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7-Benzofurancarboxylic acid, 2,3-dihydro-3-oxo-

1344897-22-8
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Yield:1344897-22-8 79%

Reaction Conditions:

with hydrogenchloride in methanol;water; for 1 h;Reflux;

Steps:

9 3-Oxo-2,3-dihydrobenzofuran-7-carboxylic acid (XXIa):

A solution of 1.4 g (6.4 mmol, 1.0 eq.) of 3-acetoxybenzofuran-7-carboxylic acid (XXa) in30 mL of conc. HC1 / H20 / MeOH (1:10:40 v/v/v) was heated at reflux for 1 h. The mixturewas allowed to cool to room temperature and the methanol removed in vacuo. The resultingsolid was collected by filtration, washed with water and dried under high vacuum to provide0.9 g (5.0 mmol, 79%) of 3-oxo-2,3-dihydrobenzofuran-7-carboxylic acid (XXIa).

References:

WO2018/172852,2018,A1 Location in patent:Page/Page column 214; 217-218

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1344897-22-8
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References

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1344897-22-8
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References

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1344897-22-8
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References

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Benzoic acid, 2-(carboxymethoxy)-3-methyl-

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1344897-22-8
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References