7-CHLORO-3-HYDROXY-3H-ISOBENZOFURAN-1-ONE synthesis
- Product Name:7-CHLORO-3-HYDROXY-3H-ISOBENZOFURAN-1-ONE
- CAS Number:70097-44-8
- Molecular formula:C8H5ClO3
- Molecular Weight:184.58
124-38-9
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3395-80-0
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70097-44-8
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Yield:70097-44-8 28%
Reaction Conditions:
Stage #1: 1,1-dimethoxy-1-(3-chlorophenyl)methanewith sec.-butyllithium in tetrahydrofuran;hexane at -70; for 0.5 h;
Stage #2: carbon dioxide in tetrahydrofuran;hexane at -70 - 20;
Stage #3: with hydrogenchloride in tetrahydrofuran;hexane;water;
References:
Wang, Wei;Cha, Xue-Xiang;Reiner, John;Gao, Yuan;Qiao, Hai-Ling;Shen, Jia-Xiang;Chang, Jun-Biao [European Journal of Medicinal Chemistry,2010,vol. 45,# 5,p. 1941 - 1946] Location in patent:experimental part
118-91-2
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70097-44-8
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10345-79-6
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70097-44-8
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609-65-4
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70097-44-8
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20771-97-5
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70097-44-8
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