7-ForMyl-1-Methyl-1H-indole-3-carbonitrile synthesis
- Product Name:7-ForMyl-1-Methyl-1H-indole-3-carbonitrile
- CAS Number:1373137-76-8
- Molecular formula:C11H8N2O
- Molecular Weight:184.19
Yield:1373137-76-8 61.2%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 15 h;
Steps:
1.2 (2) Synthesis of Compound 3 (7-formyl-1-methyl-1H-indole-3-carbonitrile)
53.4 g of Compound 2 was dissolved in 600 ml of DMF, and 215 g (5 eq) of K2CO3 and 58 ml (3 eq) of CH3I were added, and the resulting mixture was stirred at room temperature for 15 hours. The termination of the reaction was confirmed, followed by performing layer separation using H2O and EA, dehydrating using MgSO4, and filtering and drying under reduced pressure. The produced solid was treated with hexane for 30 minutes thus preparing a slurry which was then filtered and dried, yielding 35.4 g (61.2%) of the title compound (Compound 3). 1H NMR (300 MHz, DMSO-d6, ppm, δ): 10.42 (s, 1H), 8.38 (s, 1H), 7.98 (d, J=8.07, 1H), 7.95 (dd, J=7.55, 1.12, 1H), 7.46 (d, J=7.62, 1H), 4.15 (S, 3H)
References:
US2013/196972,2013,A1 Location in patent:Paragraph 0086-0087
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