ChemicalBook CAS DataBase List 7-HYDROXY-4,8-DIMETHYLCOUMARIN

7-HYDROXY-4,8-DIMETHYLCOUMARIN synthesis

6synthesis methods

Product Name:7-HYDROXY-4,8-DIMETHYLCOUMARIN
CAS Number:4115-76-8
Molecular formula:C11H10O3
Molecular Weight:190.2

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105-45-3
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4115-76-8
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Yield: 95%

Reaction Conditions:

with Fe₃O₄-SiO₂-HMTA nanomaterial in neat (no solvent) at 100; for 0.25 h;Green chemistry;

Steps:

Typical procedure for the synthesis of coumarinderivatives
General procedure: A mixture of phenolic compound (1 mmol), methyl acetoacetate(0.1 g, 1 mmol) and Fe3O4-SiO2-HMTA nanomaterial(10 % mol) was stirred at 100 °C for 20 min. Then,the reaction was allowed to cool to room temperature. Aftercompletion of reaction, as monitored by TLC, the mixturewas diluted with EtOH (2 mL). The catalyst was separatedby an external magnet and the product was purified byrecrystallization from EtOH.

References:

Kangari, Sahar;Yavari, Issa;Maasoumi, Bakhshali [Journal of the Iranian Chemical Society,2015,vol. 12,# 10,p. 1771 - 1779]

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141-97-9 Synthesis