7-Hydroxy-5-Methoxy-2,3-dihydro-1H-inden-1-one synthesis

5synthesis methods

Product Name:7-Hydroxy-5-Methoxy-2,3-dihydro-1H-inden-1-one
CAS Number:76842-70-1
Molecular formula:C10H10O3
Molecular Weight:178.18

880-87-5
60 suppliers
$91.00/250mg

7-Hydroxy-5-Methoxy-2,3-dihydro-1H-inden-1-one

76842-70-1
25 suppliers
$175.00/50mg

Yield:76842-70-1 96%

Reaction Conditions:

with boron trichloride in dichloromethane at 0 - 20; for 5 h;

Steps:

45.3

To a solution of 5, [7-DIMETHOXY-1-INDANONE] (10.3 g, 54 [MMOL)] in dichloromethane (100 mL) at [0C] was added 1 M solution of BCI3 (102 mL, 102 [MMOL)] in dichloromethane, and the resulting solution was stirred for 2.5 h at [0C.] The mixture was warmed to rt and stirred for 2.5 h. The reaction mixture was poured into 100 g ice, and the aqueous layer was extracted with dichloromethane. Solvents were evaporated under vacuum to obtain [7-HYDROXY-5-METHOXY-1-INDANONE] (9.3 g, 52 [MMOL)] in 96% [YIELD.'H] NMR [(CDCI3)] [B] 2.7 (t, 2H), 3.1 (t, 2H), 3.9 (s, 3H), 6.3 (m, [1H),] 6.5 (m, [1H),] 9.2 (bs, [1H)] ; MS (ES) 179 (M+1) [+.]

References:

WO2004/11446,2004,A1 Location in patent:Page 73

717-94-2 Synthesis