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ChemicalBook CAS DataBase List 7-Iodo-7-deaza-D-guanosine

7-Iodo-7-deaza-D-guanosine synthesis

9synthesis methods
2-aMino-5-iodo-4-Methoxy-7-(2-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyriMidine

480439-92-7
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7-Iodo-7-deaza-D-guanosine

444020-71-7
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Yield:444020-71-7 91%

Reaction Conditions:

with sodium hydroxide for 5 h;Reflux;

Steps:

2.4 synthesis of 7-deaza-7-iodoguanosine

Compound GD (506mg, 1.20mmol) disposed 25mL sodium hydroxide solution (2N) was refluxed 5H, cooled and added to a solution of acetic acid, filtered, washed with a small amount of water, and dried to give a white solid 445mg i.e. the GI, a yield of 91%.

References:

CN103819523,2016,B Location in patent:Paragraph 0066; 0077; 0078; 0079