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Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- structure

CAS No.: 149765-16-2

Chemical Name:: Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

Synonyms: N2-Pivaloyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidine;4-chloro-5-iodo-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine;N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidin-2-yl)pivalaMide;Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2...;N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-;N2-Pivaloyl-2-amino-?4-?chloro-?5-?iodo-?7H-?pyrrolo[2,?3-?d]?pyrimidine;N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidin-2-yl)-2,2-diMethyl propanaMide;N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide;Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

CBNumber:: CB31509307

Molecular Formula:: C11H12ClIN4O

Molecular Weight:: 378.6

MDL Number:: MFCD11109808

MOL File:: 149765-16-2.mol

MSDS File:: SDS

Last updated:2026-11-04 16:55:40

Request For Quotation

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Properties

Melting point	240 °C(Solv: methanol (67-56-1))
Density	1.90±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	5.97±0.40(Predicted)
Appearance	Off-white to yellow Solid
Comptox DTXSID	DTXSID40573208

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P501-P270-P264-P301+P312+P330

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FC138201	N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide	149765-16-2	0.5g	$900	2026-06-04	Buy
Biosynth	FC138201	N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide	149765-16-2	0.25g	$900	2026-06-04	Buy
Biosynth	FC138201	N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide	149765-16-2	0.1g	$900	2026-06-04	Buy
Biosynth	FC138201	N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide	149765-16-2	0.05g	$900	2026-06-04	Buy
Biosynth	FC138201	N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide	149765-16-2	1g	$1191.1	2026-06-04	Buy

Product number	Packaging	Price	Buy
FC138201	0.5g	$900	Buy
FC138201	0.25g	$900	Buy
FC138201	0.1g	$900	Buy
FC138201	0.05g	$900	Buy
FC138201	1g	$1191.1	Buy

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Chemical Properties, Uses, Production

Synthesis

N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE

149765-15-1

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

149765-16-2

Step 4. Synthesis of N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide An anhydrous tetrahydrofuran (2L) solution of N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (101 g, 0.40 mol) was treated with N-iodosuccinimide (98.9 g, 0.44 mol, 1.1 eq.) under nitrogen protection and the reaction was stirred at room temperature for 40 min. After completion of the reaction, the solvent was removed by evaporation and the residue was dissolved in dichloromethane (1.5 L) and washed sequentially with sodium sulfite solution (500 mL x 3) and saturated saline (300 mL x 3). The organic phase was dried over anhydrous sodium sulfate, concentrated, and recrystallized from methanol to give the title compound as a white powder (122 g, 81% yield, HPLC purity: 98.2%). Retention time (tR): 6.19 min. 1H-NMR (DMSO-d6) δ: 12.65 (broad single peak, 1H), 10.11 (broad single peak, 1H), 7.76 (double peak, 1H), 1.24 (single peak, 9H).

References

[1] Synthesis, 2004, # 8, p. 1203 - 1210
[2] Heterocycles, 1993, vol. 35, # 2, p. 825 - 841
[3] Angewandte Chemie - International Edition, 2007, vol. 46, # 13, p. 2325 - 2327
[4] Patent: US2006/223797, 2006, A1. Location in patent: Page/Page column 83-84
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 17, p. 7786 - 7795

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Preparation Products And Raw materials

Raw materials

N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide N-Iodosuccinimide Tetrahydrofuran

Preparation Products

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Suppliers

Global Suppliers ( 60)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China Langchem Inc.	0086-21-58956006		China	7798	57
Nanjing Baifuli Technology Co., Ltd.	25-25-58740604 15951658055	sales@unisyn.cn	China	623	58
Shanghai Raise Chemical Technology Co.,Ltd	15026594951	rs@raise-chem.com	China	5000	55
EnliPharma Technology Co., Ltd	0551-66399836 18955197623	sales@enlipharma.com	China	1875	55
Shanghai Run-Biotech Co., Ltd.	021-57171705 13817537615	sales@run-biotech.com	China	2314	58
Zhengzhou Alfachem Co.,Ltd.	0371-53778726 18003825608	liuxiaoyan@alfachem.cn	China	1974	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
JiangYin Ruisheng Chemical Co., Ltd.	13003356808	1485751188@qq.com	China	403	55
Hangzhou Molcore Biopharmatech Co.,Ltd	400-711-5280 86-571-81025280	sales@molcore.com	China	9957	58

Supplier	Advantage
Shanghai Hanhong Scientific Co.,Ltd.	64
China Langchem Inc.	57
Nanjing Baifuli Technology Co., Ltd.	58
Shanghai Raise Chemical Technology Co.,Ltd	55
EnliPharma Technology Co., Ltd	55
Shanghai Run-Biotech Co., Ltd.	58
Zhengzhou Alfachem Co.,Ltd.	58
Amadis Chemical Company Limited	58
JiangYin Ruisheng Chemical Co., Ltd.	55
Hangzhou Molcore Biopharmatech Co.,Ltd	58

View Latest Price from Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-21	N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl ?propanamide 149765-16-2				10g	TargetMol Chemicals Inc.

N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl ?propanamide
149765-16-2
TargetMol Chemicals Inc.

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Spectrum

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-(149765-16-2)¹HNMR

149765-16-2 (Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-) Related Search:

N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide N-(4-Chloro-5-fluoro-3-iodopyridin-2-yl)pivalamide N-[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-methylesulfonamide N2-Pivaloyl-4-chloro-5-cyano-7H-pyrrolo[2,3-d]pyriMidine Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

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N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidin-2-yl)-2,2-diMethyl propanaMide N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidin-2-yl)pivalaMide 4-chloro-5-iodo-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide N2-Pivaloyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidine Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2... N2-Pivaloyl-2-amino-?4-?chloro-?5-?iodo-?7H-?pyrrolo[2,?3-?d]?pyrimidine N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- 149765-16-2 C11H12ClIN4O