4-[4-(2-BROMO-2-METHYL-1-OXOPROPYL)PHENYL]-CYCLOHEXANEACETIC ACID ETHYL ESTER synthesis

3synthesis methods

Product Name:4-[4-(2-BROMO-2-METHYL-1-OXOPROPYL)PHENYL]-CYCLOHEXANEACETIC ACID ETHYL ESTER
CAS Number:701232-18-0
Molecular formula:C20H27BrO3
Molecular Weight:395.33

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411238-92-1 Synthesis

4-PHENYL-CYCLOHEXANEACETIC ACID ETHYL ESTER

411238-92-1
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4-[4-(2-BROMO-2-METHYL-1-OXOPROPYL)PHENYL]-CYCLOHEXANEACETIC ACID ETHYL ESTER

701232-18-0
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Yield:-

Reaction Conditions:

with aluminum (III) chloride in dichloromethane at 0;Friedel Crafts Acylation;

Steps:

1

Anhydrous AlCl3 (440 mg, 3.30 mmol) was added portionwise to a solution of Compound 3 (271 mg, 1.10 mmol) in CH2C12 (1.4 mL) at 0°C and then 2-bromoisobutyryl bromide (0.14 mL, 1.10 mmol) was added dropwise. After stirring for 1 hr at 0°C, the mixture was poured into iced water and extracted with CHC13 (5 mL). The combined organic layer was washed successively with saturated aqueous NaHCO3 solution (5 mL) and brine (5 mL), dried over MgS04 and concentrated. The residue was purified by column chromatography (hexane/AcOEt=7/1) to give Compound 4 (402 mg) as a colorless oil.

References:

WO2005/72740,2005,A2 Location in patent:Page/Page column 66-67

2-(4-PHENYLCYCLOHEXYLIDENE)-ACETIC ACID ETHYL ESTER

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701232-18-0
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References

4894-75-1
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701232-18-0
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References