![](/CAS/20180629/GIF/708274-37-7.gif)
8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol synthesis
- Product Name:8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol
- CAS Number:708274-37-7
- Molecular formula:C13H16BrNO3
- Molecular Weight:314.17
![2,5-Dibromopyridine](/CAS/GIF/624-28-2.gif)
624-28-2
715 suppliers
$5.00/5g
![1,4-Dioxaspiro[4.5]decan-8-one](/CAS/GIF/4746-97-8.gif)
4746-97-8
467 suppliers
$5.00/1g
![8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol](/CAS/20180629/GIF/708274-37-7.gif)
708274-37-7
24 suppliers
$63.00/500mg
Yield:708274-37-7 79%
Reaction Conditions:
Stage #1: 2,5-dibromopyridinewith n-butyllithium in toluene at -78; for 2.5 h;
Stage #2: cyclohexanedione monoethylene ketal in dichloromethane;toluene at -78 - 20;
References:
Xue, Chu-Biao;Wang, Anlai;Han, Qi;Zhang, Yingxin;Cao, Ganfeng;Feng, Hao;Huang, Taisheng;Zheng, Changsheng;Xia, Michael;Zhang, Ke;Kong, Lingquan;Glenn, Joseph;Anand, Rajan;Meloni, David;Robinson;Shao, Lixin;Storace, Lou;Li, Mei;Hughes, Robert O.;Devraj, Rajesh;Morton, Philip A.;Rogier, D. Joseph;Covington, Maryanne;Scherle, Peggy;Diamond, Sharon;Emm, Tom;Yeleswaram, Swamy;Contel, Nancy;Vaddi, Kris;Newton, Robert;Hollis, Greg;Metcalf, Brian [ACS Medicinal Chemistry Letters,2011,vol. 2,# 12,p. 913 - 918] Location in patent:supporting information; experimental part
![1,4-Dioxaspiro[4.5]decan-8-one](/CAS/GIF/4746-97-8.gif)
4746-97-8
467 suppliers
$5.00/1g
![8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol](/CAS/20180629/GIF/708274-37-7.gif)
708274-37-7
24 suppliers
$63.00/500mg