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6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: acetic anhydride; zinc(II) chloride / 4 h / Inert atmosphere; Reflux
2: ethanol / 2 h / Reflux
3: diphenylether / 1 h / Reflux

References:

Cui, Sheng-Feng;Ren, Yu;Zhang, Shao-Lin;Peng, Xin-Mei;Damu, Guri L.V.;Geng, Rong-Xia;Zhou, Cheng-He [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 11,p. 3267 - 3272]