2-[[(TERT-BUTOXYCARBONYL)AMINO]METHYL]THIAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:2-[[(TERT-BUTOXYCARBONYL)AMINO]METHYL]THIAZOLE-4-CARBOXYLIC ACID
- CAS Number:71904-80-8
- Molecular formula:C10H14N2O4S
- Molecular Weight:258.29
96929-05-4
93 suppliers
$56.00/250mg
71904-80-8
32 suppliers
$196.00/250mg
Yield:71904-80-8 100%
Reaction Conditions:
with potassium hydroxide in tetrahydrofuran;water at 20; for 1 h;
Steps:
General procedure for hydrolisis of methyl/ethyl esters.
General procedure: KOH aq. (10%) was added to a solution of the ester in THF and the reaction mixture was stirred at room temperature for 1h. The pH was brought to 4 by addition of 5M HCl and then extracted with EtOAc. The organic layer was dried over MgSO4 and concentrated in vacuo to afford the acid.
References:
Pena, Stella;Scarone, Laura;Manta, Eduardo;Stewart, Lindsay;Yardley, Vanessa;Croft, Simon;Serra, Gloria [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 15,p. 4994 - 4997] Location in patent:supporting information; experimental part
297165-32-3
15 suppliers
$197.75/250mg
71904-80-8
32 suppliers
$196.00/250mg
1113-59-3
292 suppliers
$14.00/1g
89226-13-1
61 suppliers
$45.00/250mg
71904-80-8
32 suppliers
$196.00/250mg
35150-09-5
95 suppliers
$30.00/5g
71904-80-8
32 suppliers
$196.00/250mg
89226-13-1
61 suppliers
$45.00/250mg
71904-80-8
32 suppliers
$196.00/250mg