4-BROMO-1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE synthesis
- Product Name:4-BROMO-1,5-DIMETHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
- CAS Number:721402-02-4
- Molecular formula:C6H6BrF3N2
- Molecular Weight:243.02
60061-68-9
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74-88-4
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721402-02-4
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Yield:721402-02-4 85%
Reaction Conditions:
with potassium carbonate in acetone at 60; for 4 h;
Steps:
85.1 Step 1:
Add 4-bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazole (85-a, 2 g, 8.7 mmol) into a 100 mL single-necked bottle, add 40 mL of acetone as a solvent, and then sequentially Potassium carbonate (2.4 g, 17.4 mmol), iodomethane (2.4 g, 17.4 mmol) were added, and the mixture was stirred at 60° C. for 4 h.After the completion of the reaction was detected by TLC, the reaction solution was extracted with ethyl acetate, and the organic phase was concentrated to obtain 4-bromo-1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole (85-b, 1.82 g, 7.39 mmol, 85% yield).
References:
WO2022/152229,2022,A1 Location in patent:Page/Page column 92
79080-31-2
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721402-02-4
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10010-93-2
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721402-02-4
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367-57-7
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721402-02-4
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