ChemicalBook CAS DataBase List 4-(6-fluoro-3-pyridinyl)-1-piperidinecarboxylic acid tert-butyl ester

4-(6-fluoro-3-pyridinyl)-1-piperidinecarboxylic acid tert-butyl ester synthesis

4synthesis methods

Product Name:4-(6-fluoro-3-pyridinyl)-1-piperidinecarboxylic acid tert-butyl ester
CAS Number:741683-17-0
Molecular formula:C15H21FN2O2
Molecular Weight:280.34

1-Piperidinecarboxylic acid, 4-(6-fluoro-3-pyridinyl)-4-hydroxy-, 1,1-dimethylethyl ester

741683-15-8
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4-(6-fluoro-3-pyridinyl)-1-piperidinecarboxylic acid tert-butyl ester

741683-17-0
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Yield:741683-17-0 94.33%

Reaction Conditions:

with ethanol for 5 h;Reflux;Large scale;Concentration;

Steps:

3.2 Step 2: Synthesis of 4-(6-fluoro-3-pyridyl)-N-tert-butoxycarbonylpiperidine

4-(6-Fluoro-3-pyridyl)-4-hydroxy-N-tert-butoxycarbonylpiperidine (3.92 kg, 13.2 mol) and Raney nickel (1 kg, 17.0 mol) were added to ethanol (50 L) for reaction. The liquid was refluxed for 5 hours and then cooled to room temperature. Raney nickel was filtered and the solution was spin-dried to obtain 3.50 kg of solid with a yield of 94.33%.

References:

CN107759563,2018,A Location in patent:Paragraph 0040-0041; 0052-0053; 0063; 0064

741683-16-9 Synthesis

4-(6-fluoro-3-pyridinyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

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741683-17-0
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References

766-11-0 Synthesis

766-11-0
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79099-07-3 Synthesis

79099-07-3
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$5.00/5g

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References