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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate
74288-40-7

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate synthesis

6synthesis methods
74288-39-4 Synthesis
2-Azetidinebutanoic acid, a-diazo-3-(1-hydroxyethyl)-b,4-dioxo-, (4-nitrophenyl)Methyl ester, [2R-[2a,3b(R*)]]-

74288-39-4
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p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

74288-40-7
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-

Yield:-

Reaction Conditions:

rhodium (II) octanoate dimer in dichloromethane; for 4 - 5 h;Heating / reflux;

Steps:

3

(3S, 4R)-3- [ (LR)-HYDROXYETHYL]-4- [3- (4-NITROBENZYLOXY) CARBONYL-2-OXO-3- diazopropyl] azetidin-2-one (250 g) and rhodium octanoate dimmer (1.0 g) were added to dichloromethane (2.5 L) and heated to reflux for 4 to 5 hours. The reaction was monitored by HPLC until unreacted azetidinone was not more than 2.0%. To the clear dichloromethane solution, cyclohexane was added to precipitate the product at 20 °C to 30 °C. The product was filtered, washed with cyclohexane and dried. Yield: 188g

References:

WO2005/21560,2005,A1 Location in patent:Page/Page column 13

2-Azetidinecarboxylic acid, 3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1-[(4-methylphenyl)sulfonyl]-4-oxo-, phenylmethyl ester, (2R,3S)-

1180012-46-7
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p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

74288-40-7
236 suppliers
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References
2-Azetidinecarboxylic acid, 3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4-oxo-, phenylmethyl ester, (2R,3S)-

1180012-50-3
0 suppliers
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p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

74288-40-7
236 suppliers
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References
3-Butenoic acid, 2-diazo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester

93788-48-8
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p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

74288-40-7
236 suppliers
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References
2-Azetidinecarboxylic acid, 3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4-oxo-, (2R,3S)-

115936-64-6
0 suppliers
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p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

74288-40-7
236 suppliers
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References

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate Related Search:

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