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1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-Methyl-1-(phenylsulfonyl)- synthesis

3synthesis methods
-

Yield:744209-64-1 85%

Reaction Conditions:

Stage #1: 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridinewith lithium diisopropyl amide in tetrahydrofuran at -30; for 0.666667 h;
Stage #2: methyl iodide in tetrahydrofuran at 20; for 16 h;

References:

Mendiola, Javier;Baeza, Alejandro;Alvarez-Builla, Julio;Vaquero, Juan J. [Journal of Organic Chemistry,2004,vol. 69,# 15,p. 4974 - 4983]