(R)-2-(4-CYCLOPROPANESULFONYLPHENYL)-3-(TETRAHYDROPYRAN-4-YL)PROPIONIC ACID synthesis

7synthesis methods

Product Name:(R)-2-(4-CYCLOPROPANESULFONYLPHENYL)-3-(TETRAHYDROPYRAN-4-YL)PROPIONIC ACID
CAS Number:745053-49-0
Molecular formula:C17H22O5S
Molecular Weight:338.42

2H-Pyran-4-propanoic acid, α-[4-(cyclopropylthio)phenyl]tetrahydro-, (αR)-

1001327-35-0
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(R)-2-(4-CYCLOPROPANESULFONYLPHENYL)-3-(TETRAHYDROPYRAN-4-YL)PROPIONIC ACID

745053-49-0
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Yield:745053-49-0 91%

Reaction Conditions:

with oxone(R) in water;isopropyl alcohol at 20; for 18 h;

Steps:

14.A.viii

To a solution of the acid Part A(vii) compound(0.9 g, 2.94 mmol) in isopropanol (20 ml) and water (10.00 ml) was added oxone (4.15 g, 6.76 mmol). The reaction was stirred at RT for 18 h. The reaction was filtered, and the filtrate was concentrated in vacuo. The residue was taken up in EtOAc and was washed with H₂O and Brine. The organic layer was dried [MgSO₄], filtered, and concentrated in vacuo to give the Part A(viii) compound (0.9 g, 91% yield) as a pale-yellow foam.

References:

US2008/21052,2008,A1 Location in patent:Page/Page column 34

745052-98-6 Synthesis