(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid synthesis

5synthesis methods

Product Name:(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid
CAS Number:745052-98-6
Molecular formula:C17H20O5S
Molecular Weight:336.4027

745052-94-2 Synthesis

ethyl 2-(4-(cyclopropylthio)phenyl)-2-oxoacetate

745052-94-2
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$482.00/1g

745052-92-0 Synthesis

Triphenyl[(tetrahydro-2H-pyran-4-yl)methyl]phosphonium iodide

745052-92-0
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(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

745052-98-6
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Yield:745052-98-6 132.9 kg

Reaction Conditions:

Stage #1: triphenyl((tetrahydro-2H-pyran-4-yl)methyl)phosphonium iodidewith lithium hexamethyldisilazane in tetrahydrofuran at 0 - 20; for 3 h;Large scale reaction;Wittig olefination;
Stage #2: ethyl 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetate in tetrahydrofuran at 0 - 20;Large scale reaction;Further stages;Wittig olefination;

References:

Magnus, Nicholas A.;Braden, Timothy M.;Buser, Jonas Y.;Debaillie, Amy C.;Heath, Perry C.;Ley, Christopher P.;Remacle, Jacob R.;Varie, David L.;Wilson, Thomas M. [Organic Process Research and Development,2012,vol. 16,# 5,p. 830 - 835] Location in patent:experimental part

876063-40-0 Synthesis

ETHYL (4-CYCLOPROPYLSULFONYLPHENYL)OXOACETATE

876063-40-0
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745052-98-6
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References

745052-92-0 Synthesis

745052-92-0
24 suppliers
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876063-40-0 Synthesis

876063-40-0
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745052-98-6
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References

ethyl 2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylate

745052-96-4
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745052-98-6
16 suppliers
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References

14633-54-6
145 suppliers
$22.00/1g

745052-98-6
16 suppliers
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References