![](/CAS2/GIF/756503-69-2.gif)
5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine synthesis
- Product Name:5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
- CAS Number:756503-69-2
- Molecular formula:C13H10BrCl2FN2O
- Molecular Weight:380.04
![3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine](/CAS2/GIF/756520-67-9.gif)
756520-67-9
18 suppliers
inquiry
![5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine](/CAS2/GIF/756503-69-2.gif)
756503-69-2
15 suppliers
inquiry
Yield:756503-69-2 82%
Reaction Conditions:
with N-Bromosuccinimide in dichloromethane;acetonitrile at 0; for 0.166667 h;
Steps:
1.4 Step 4 (±)-5-bromo-3-(1 -(2,6-dichloro-3-fluoropheny)ethoxy)pyridin- 2-amine
Step 4 (±)-5-bromo-3-(1 -(2,6-dichloro-3-fluoropheny)ethoxy)pyridin- 2-amine [00167] To a solution of 3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridine-2-amine (7.49g, 24.87 mmol) in CH3CN/DCM ( 00/30 mL) was added NBS (4.43 g, 24.87 mmol) in portions at 0 °C. The reaction solution was stirred at 0 °C for 10 min. The precipitate was removed by filtration. The black filtrate was concentrated to give a black residue which was purified by CombiFlash (80 g silica gel column, EtOAc/Hexane) to afford 5- bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine (7.8 g, 82%) as a pale yellow solid. [00168] 1HNMR (300 MHz, CDCI3): δ 7.67 (d, 1 H), 7.31 (dd, 1 H), 7.08 (t, 1 H), 6.83 (s, 1 H), 4.83 (s, br, 2 H), 1.82 (t, 3 H).
References:
WO2013/13308,2013,A1 Location in patent:Paragraph 00166-00168
![2-(1-bromoethyl)-1,3-dichloro-4-fluorobenzene](/CAS/20180703/GIF/1331786-28-7.gif)
1331786-28-7
6 suppliers
inquiry
![2-amino-5-bromopyridin-3-ol](/CAS/GIF/39903-01-0.gif)
39903-01-0
219 suppliers
$15.00/1g
![5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine](/CAS2/GIF/756503-69-2.gif)
756503-69-2
15 suppliers
inquiry
![1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANOL](/CAS/GIF/756520-66-8.gif)
756520-66-8
91 suppliers
$10.00/1g
![5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine](/CAS2/GIF/756503-69-2.gif)
756503-69-2
15 suppliers
inquiry
![3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine](/CAS2/GIF/756521-08-1.gif)
756521-08-1
15 suppliers
inquiry
![5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine](/CAS2/GIF/756503-69-2.gif)
756503-69-2
15 suppliers
inquiry
![2,6-Dichloro-3-fluoroacetophenone](/CAS/GIF/290835-85-7.gif)
290835-85-7
259 suppliers
$6.00/10g
![5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine](/CAS2/GIF/756503-69-2.gif)
756503-69-2
15 suppliers
inquiry