ChemicalBook CAS DataBase List BenzenesulfonaMide, 2-[(2,5-dichloro-4-pyriMidinyl)aMino]-N-Methyl-

BenzenesulfonaMide, 2-[(2,5-dichloro-4-pyriMidinyl)aMino]-N-Methyl- synthesis

3synthesis methods

Product Name:BenzenesulfonaMide, 2-[(2,5-dichloro-4-pyriMidinyl)aMino]-N-Methyl-
CAS Number:761440-11-3
Molecular formula:C11H10Cl2N4O2S
Molecular Weight:333.19

16288-77-0
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5750-76-5 Synthesis

5750-76-5
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BenzenesulfonaMide, 2-[(2,5-dichloro-4-pyriMidinyl)aMino]-N-Methyl-

761440-11-3
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Yield:761440-11-3 50%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 45; for 15 h;

Steps:

4a

4a) A mixture of 2-amino-N-methyl-benzenesulfonamide (2.93, 15.75 mmol), 2,4,5 trichloropyrimidine (2.9 g, 15.84 mmol) and K₂CO₃ (4.5g, 32.6 mmol) in dry DMF (25 mL) was stirred at 45?°C for 15 h. The solvent was removed and the residue was taken in EPO water and was extracted twice from ethylacetate. Combined organic was washed with water and brine. After drying solvent was removed. Upon triturating with ether and filtration gave the product 2-(2,5-Dichloro-pyrimidin-4-ylamino)-??/-methyl- benzenesulfonamide 7 as a white solid (2.6g, 50%); ¹H NMR (400 MHz, CDCl₃) 59.61 (s, I H), 8.6 (d = 12. 89 Hz, IH), 8.53 (s, IH), 8.27 (s, IH), 7.68 (m, IH), 7.27 (m, IHO, 1.66 (br s, IHO, 2.66 (s, 3H).

References:

WO2008/51547,2008,A1 Location in patent:Page/Page column 304-305

1694-92-4 Synthesis

1694-92-4
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761440-11-3
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References

23530-40-7 Synthesis

23530-40-7
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761440-11-3
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References