ChemicalBook CAS DataBase List Ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

Ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate synthesis

6synthesis methods

Product Name:Ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
CAS Number:78756-37-3
Molecular formula:C15H14BrN3O3
Molecular Weight:364.19

105-56-6
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78756-36-2 Synthesis

7-BROMO-4-METHYL-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE

78756-36-2
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Ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

78756-37-3
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Yield:78756-37-3 40%

Reaction Conditions:

Stage #1: 7-bromo-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dionewith diethyl chlorophosphate;lithium diisopropyl amide in tetrahydrofuran at 0;
Stage #2: ethyl 2-cyanoacetatewith lithium diisopropyl amide in tetrahydrofuran;

References:

Li, Xiaoyan;Cao, Hui;Zhang, Chunchun;Furtmueller, Roman;Fuchs, Karoline;Huck, Sigismund;Sieghart, Werner;Deschamps, Jeffrey;Cook, James M. [Journal of Medicinal Chemistry,2003,vol. 46,# 26,p. 5567 - 5570]

2999-46-4
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78756-36-2 Synthesis

78756-36-2
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78756-37-3
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References

4-METHYL-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE

3415-35-8
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78756-37-3
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References

2999-46-4
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78756-37-3
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References

118-48-9 Synthesis

118-48-9
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78756-37-3
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References