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ChemicalBook CAS DataBase List 3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester

3-(2,2,2-trifluoro-acetylaMino)-thiophene-2-carboxylicacidMethylester synthesis

2synthesis methods
22288-78-4 Synthesis
Methyl 3-amino-2-thiophenecarboxylate

22288-78-4
385 suppliers
$11.00/5g

407-25-0 Synthesis
Trifluoroacetic anhydride

407-25-0
437 suppliers
$9.00/1g

-

Yield:79128-68-0 99%

Reaction Conditions:

with pyridine in acetonitrile at 0; for 2 h;

References:

Zhang, Mingzhu;Tamiya, Junko;Nguyen, Linh;Rowbottom, Martin W.;Dyck, Brian;Vickers, Troy D.;Grey, Jonathan;Schwarz, David A.;Heise, Christopher E.;Haelewyn, Jason;Mistry, Monica S.;Goodfellow, Val S. [Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,# 9,p. 2535 - 2539]