ChemicalBook CAS DataBase List Methyl 3-amino-2-thiophenecarboxylate

Methyl 3-amino-2-thiophenecarboxylate synthesis

5synthesis methods

Product Name:Methyl 3-amino-2-thiophenecarboxylate
CAS Number:22288-78-4
Molecular formula:C6H7NO2S
Molecular Weight:157.19

2365-48-2 Synthesis

2365-48-2
341 suppliers
$14.00/25g

920-37-6 Synthesis

920-37-6
302 suppliers
$10.60/1gm:

22288-78-4
389 suppliers
$11.00/5g

Yield:22288-78-4 57%

Reaction Conditions:

with sodium methoxide in methanol at 0 - 20; for 1 h;

Steps:

1 Example 1 Synthesis of methyl 3-aminothiophene-2-carboxylate 1

Methyl thioglycolate (10.6 g, 100 mmol) and NaOMe (10.8 g, 200 mmol) were dissolved in MeOH (90 mL) followed by 2-chloroacrylonitrile (8.75 g, 100 mmol) in MeOH (10 mL) and added at 0 It was added dropwise to a round-bottomed flask at and stirred at room temperature for 1 h. After monitoring the reaction by TLC, the reaction mixture was concentrated under reduced pressure, added H2O (50 mL), extracted with EtOAc (4×50 mL), the organic phase was dried with MgSO4, filtered and concentrated under reduced pressure, and the corresponding product 1 (8.95 g) was obtained by silica gel column separation. ), white solid, melting point: 42°C, yield: 57%.

References:

CN114213400,2022,A Location in patent:Paragraph 0043-0047

79128-68-0 Synthesis