8-Nitroquinazoline-2,4-diol synthesis
- Product Name:8-Nitroquinazoline-2,4-diol
- CAS Number:174565-61-8
- Molecular formula:C8H5N3O4
- Molecular Weight:207.14
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Yield:174565-61-8 7.70 g (63%)
Reaction Conditions:
with urea in water;
Steps:
20.a 7-Nitro-2,3,5,6-tetrahydro-1,2,4-triazolo[4,3-c]quinazoline-3,5-dione
a) A mixture of 10.7 g (0.059 mol) of 2-amino-3-nitrobenzoic acid and 21.6 g (0.35 mol) of urea was heated to 180° C. for 5 hrs. The resulting brown mass was ground in a mortar, suspended in water overnight, filtered off, washed with water and subsequently with acetone and dried in a vacuum. Yield: 7.70 g (63%) of 8-nitro-1,2,3,4-tetrahydroquinazoline-2,4-dione as brownish crystals; m.p. 277°-276° C. (dec.).
References:
US5688803,1997,A
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313279-12-8
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