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ChemicalBook CAS DataBase List ethyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate
808116-52-1

ethyl 4-hydroxy-7-phenoxyisoquinoline-3-carboxylate synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: pyridine; quinoline; copper(II) oxide; potassium carbonate / 28 h / 170 °C / Inert atmosphere
2.1: methanol / 25 - 30 °C
2.2: 10 - 15 °C
3.1: phosphorus tribromide / dichloromethane / -10 - 0 °C
4.1: sodium carbonate / acetonitrile / 55 °C
5.1: trichlorophosphate / N,N-dimethyl-formamide / 6 h / 158 °C
6.1: hydrogenchloride / water; ethanol / Reflux
6.2: 30 - 50 °C

References:

CN115594631,2023,A