1-BOC-4-(4-CHLOROPHENYL)-4-PIPERIDINEDICARBOXYLIC ACID METHYL ESTER synthesis

5synthesis methods

Product Name:1-BOC-4-(4-CHLOROPHENYL)-4-PIPERIDINEDICARBOXYLIC ACID METHYL ESTER
CAS Number:849106-01-0
Molecular formula:C18H24ClNO4
Molecular Weight:353.84

644981-94-2 Synthesis

N-BOC-4-(P-CHLOROPHENYL)-4-PIPERIDINE CARBOXYLIC ACID

644981-94-2
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$70.00/50mg

18107-18-1
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1-BOC-4-(4-CHLOROPHENYL)-4-PIPERIDINEDICARBOXYLIC ACID METHYL ESTER

849106-01-0
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Yield:849106-01-0 335 mg

Reaction Conditions:

in methanol at 20; for 0.5 h;

Steps:

44.A Step A: 1-tert-Butyl 4-methyl 4-(4-chlorophenyl)piperi dine- 1,4- dicarboxylate:

to a slotion of l-(tert-butoxycarbonyl)-4-(4-chlorophenyl)piperidine-4- carboxylic acid (296 mg, 0.871 mmol) in methanol (2904 μ) at rt was added (0194) trimethylsilyl diazomethane (871 μ, 1.742 mmol), and the reaction mixture was stirred at rt for 30 min. Methanol was removed in vacuo, water was added and the aqueous layer was extracted with ethyl acetate (x3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and filtered, and the filltrate was evaporated in vacuo to give 1-tert-butyl 4-methyl 4-(4-chlorophenyl)piperi dine- 1 ,4-dicarboxy late (335 mg) as a yellow oil. This material was used directly for the reduction reaction. NMR (500MHz, CHLOROFORM-d) δ 7.35 - 7.29 (m, 4H), 3.97 (br. s., 2H), 3.69 (s, 3H), 3.02 (br. s., 2H), 2.51 (d, J=13.1 Hz, 2H), 1.83 (br. s., 2H), 1.47 (s, 9H).

References:

WO2018/81384,2018,A1 Location in patent:Page/Page column 56

644981-94-2 Synthesis

644981-94-2
31 suppliers
$70.00/50mg