ChemicalBook CAS DataBase List N-[4-(2,4,6-Trimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide

N-[4-(2,4,6-Trimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide synthesis

5synthesis methods

Product Name:N-[4-(2,4,6-Trimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide
CAS Number:849513-58-2
Molecular formula:C18H17N3OS
Molecular Weight:323.41

55-22-1 Synthesis

55-22-1
620 suppliers
$5.00/5g

81529-60-4 Synthesis

4-(2,4,6-TRIMETHYL-PHENYL)-THIAZOL-2-YLAMINE

81529-60-4
26 suppliers
$45.00/25mg

N-[4-(2,4,6-Trimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide

849513-58-2
17 suppliers
$172.47/50mg

Yield:849513-58-2 77%

Reaction Conditions:

Stage #1: pyridine-4-carboxylic acidwith 1,1'-carbonyldiimidazole in dichloromethane at 20; for 2 h;
Stage #2: 4-(2,4,6-trimethylphenyl)thiazol-2-ylamine in dichloromethane at 20;

Steps:

General Procedure II for the Synthesis of 4-Aryl-2-amidothiazoles. To a suspension of arylcarboxylic acid (1.5 equiv) in dichloromethane was added 1,1'-carbonyldiimidazole (CDI, 3.0 equiv). After being stirred at room temperature for 2.0 h, the solution was added with 4-arylthiazol-2-amine (q.0 equiv). The reaction mixture was stirred at room temperature overnight. The solution was concentrated and the residue was re-dissolved in dichloromethane. The solution was washed with brine, dried over MgSO₄, and concentrated under reduced pressure to give the corresponding 4-aryl-2-amidothiazoles.

References:

US2011/230486,2011,A1 Location in patent:Page/Page column 47-48

14254-57-0 Synthesis