N-[4-(2,4,6-Trimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide synthesis
- Product Name:N-[4-(2,4,6-Trimethylphenyl)-2-thiazolyl]-4-pyridinecarboxamide
- CAS Number:849513-58-2
- Molecular formula:C18H17N3OS
- Molecular Weight:323.41
55-22-1
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81529-60-4
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849513-58-2
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$172.47/50mg
Yield:849513-58-2 77%
Reaction Conditions:
Stage #1: pyridine-4-carboxylic acidwith 1,1'-carbonyldiimidazole in dichloromethane at 20; for 2 h;
Stage #2: 4-(2,4,6-trimethylphenyl)thiazol-2-ylamine in dichloromethane at 20;
Steps:
General Procedure II for the Synthesis of 4-Aryl-2-amidothiazoles. To a suspension of arylcarboxylic acid (1.5 equiv) in dichloromethane was added 1,1'-carbonyldiimidazole (CDI, 3.0 equiv). After being stirred at room temperature for 2.0 h, the solution was added with 4-arylthiazol-2-amine (q.0 equiv). The reaction mixture was stirred at room temperature overnight. The solution was concentrated and the residue was re-dissolved in dichloromethane. The solution was washed with brine, dried over MgSO4, and concentrated under reduced pressure to give the corresponding 4-aryl-2-amidothiazoles.
References:
US2011/230486,2011,A1 Location in patent:Page/Page column 47-48
14254-57-0
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81529-60-4
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849513-58-2
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$172.47/50mg
4225-92-7
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849513-58-2
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1667-01-2
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849513-58-2
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108-67-8
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849513-58-2
17 suppliers
$172.47/50mg