4-(4-CHLOROPHENYL)PYRROLIDINE-3-METHYLCARBOXYLATE HYDROCHLORIDE synthesis

Yield:862283-71-4 100%

Reaction Conditions:

Stage #1: (3S,4R)-methyl 1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylatewith carbonochloridic acid 1-chloro-ethyl ester in toluene at 20; for 3.5 h;
Stage #2: with hydrogenchloride in toluene;

References:

Hutton, Jennie A.;Goncalves, Victor;Brannigan, James A.;Paape, Daniel;Wright, Megan H.;Waugh, Thomas M.;Roberts, Shirley M.;Bell, Andrew S.;Wilkinson, Anthony J.;Smith, Deborah F.;Leatherbarrow, Robin J.;Tate, Edward W. [Journal of Medicinal Chemistry,2014,vol. 57,# 20,p. 8664 - 8670] Location in patent:supporting information