![](/CAS/GIF/1078-21-3.gif)
Phenibut synthesis
- Product Name:Phenibut
- CAS Number:1078-21-3
- Molecular formula:C10H13NO2
- Molecular Weight:179.22
Fenibut synthesis: from benzoyl chloride and ethyl acetoacetate as raw materials, through condensation and hydrolysis of ethyl benzoyl acetate, and then condensation of benzaldehyde and nitromethane to generate trans-nitrostyrene, and then the two are combined. Micheal addition, the adduct is then catalytically hydrogenated with Raney nickel, and finally hydrolyzed in concentrated hydrochloric acid to produce phenibate.
![Synthesis of Phenibut (16) and Baclofen (17)](/NewsImg/2022-07-22/6379412310849717832589989.jpg)
Synthesis of Phenibut (16) and Baclofen (17).
![4-Phenyl-2-pyrrolidinone](/CAS/GIF/1198-97-6.gif)
1198-97-6
125 suppliers
$21.00/250mg
![Phenibut](/CAS/GIF/1078-21-3.gif)
1078-21-3
338 suppliers
$40.00/1g
Yield:-
Reaction Conditions:
with hydrogenchloride at 10;Reflux;
Steps:
2.2.1.6. Synthesis of Amino-3-phenylbutanoic acid (7)
The solution of Phenylpyrrolidin-2-one (6) (80 mg, 0.55mmol)watirredinHCl(6N)underrefluxat1°Cfor241H NMR (300 MHz, D2O) d 2.65 (dd, 1H, J 15.8 and 8.8Hz), 2.75 (dd, 1H, J 15.8 and 5.3 Hz), 3.10-3.30 (m, 3H),7.26-7.36 (m, 5H); 13C NMR (75 MHz, D2O) d 40.7, 42.4,46.3, 130.3, 130.8, 131.8, 140.8, 177.9. IR (KBr film, cm-1): = 3317-2567, 1711, 1590, 1515, 1485, 1402, 1259, 1199,1146, 972, 860, 761, 701.
References:
Keniche, Assia;El Ouar, Ibtissem;Zeghina, Ibtissem;Dib, Mohammed El Amine [Combinatorial Chemistry and High Throughput Screening,2022,vol. 25,# 1,p. 187 - 196]
![BETA-(NITROMETHYL)-BENZENEPROPANOIC ACID](/CAS/GIF/41441-41-2.gif)
41441-41-2
4 suppliers
inquiry
![Phenibut](/CAS/GIF/1078-21-3.gif)
1078-21-3
338 suppliers
$40.00/1g
![3-CYANO-3-PHENYLPROPANOIC ACID](/CAS/GIF/14387-18-9.gif)
14387-18-9
23 suppliers
inquiry
![Phenibut](/CAS/GIF/1078-21-3.gif)
1078-21-3
338 suppliers
$40.00/1g
![Benzaldehyde](/CAS/GIF/100-52-7.gif)
100-52-7
942 suppliers
$20.37/250g
![Phenibut](/CAS/GIF/1078-21-3.gif)
1078-21-3
338 suppliers
$40.00/1g
![Benzyl alcohol](/CAS/GIF/100-51-6.gif)
100-51-6
1385 suppliers
$5.00/100g
![Phenibut](/CAS/GIF/1078-21-3.gif)
1078-21-3
338 suppliers
$40.00/1g