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6-Bromo-3-hydroxy-benzo[b]thiophene-2-carboxylic acid methyl ester synthesis

2synthesis methods
2365-48-2 Synthesis
Methyl thioglycolate

2365-48-2
343 suppliers
$14.00/25g

179232-29-2 Synthesis
Methyl 4-bromo-2-fluorobenzoate

179232-29-2
216 suppliers
$9.00/5g

6-Bromo-3-hydroxy-benzo[b]thiophene-2-carboxylic acid methyl ester

863904-21-6
19 suppliers
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Yield:863904-21-6 72%

Reaction Conditions:

with lithium hydroxide in N,N-dimethyl-formamide at 0 - 20;

References:

Moretto;Kirincich;Xu;Smith;Wan;Wilson;Follows;Binnun;Joseph-McCarthy;Foreman;Erbe;Zhang;Tam;Tam;Lee [Bioorganic and Medicinal Chemistry,2006,vol. 14,# 7,p. 2162 - 2177]