![](/CAS/GIF/179232-29-2.gif)
Methyl 4-bromo-2-fluorobenzoate synthesis
- Product Name:Methyl 4-bromo-2-fluorobenzoate
- CAS Number:179232-29-2
- Molecular formula:C8H6BrFO2
- Molecular Weight:233.03
![4-Bromo-2-fluorobenzoic acid](/CAS/GIF/112704-79-7.gif)
112704-79-7
515 suppliers
$15.00/5 g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
207 suppliers
$33.00/5g
![Methyl 4-bromo-2-fluorobenzoate](/CAS/GIF/179232-29-2.gif)
179232-29-2
216 suppliers
$9.00/5g
Yield:179232-29-2 100%
Reaction Conditions:
in tetrahydrofuran;methanol;hexanes at 0 - 20; for 1 h;
Steps:
45.1
STEP 1 : To a solution of 4-bromo-2-fluorobenzoic acid (2.0 g, 9.1 mmol) in THF (24 mL) and methanol (6 mL) at 0 °C was added a solution of (trimethylsilyl)diazomethane in hexanes (2.0 M, 5.46 mL, 10.9 mmol). The yellow solution was allowed to gradually warm to room temperature over 1 h. The volatile materials were removed and the residue was treated with aqueous hydrochloric acid (1 M). The aqueous mixture was extracted with ethyl acetate. The organic extract was dried over magnesium sulfate, filtered, and concentrated to provide crude methyl 4- bromo-2-fluorobenzoate (2.7 g, quantitative yield). This material was used in the subsequent step without further purification. 1H NMR (400 MHz, CDCl3): 7.85-7.81 (m, IH), 7.38-7.33 (m, 2H), 3.93 (s, 3H); MS (EI) for C8H6BrFO2: 232, 234 (MH+).
References:
EXELIXIS, INC. WO2009/55077, 2009, A1 Location in patent:Page/Page column 447
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$7.29/5ml-f
![4-Bromo-2-fluorobenzoic acid](/CAS/GIF/112704-79-7.gif)
112704-79-7
515 suppliers
$15.00/5 g
![Methyl 4-bromo-2-fluorobenzoate](/CAS/GIF/179232-29-2.gif)
179232-29-2
216 suppliers
$9.00/5g
![4-Bromo-2-fluorobenzoic acid](/CAS/GIF/112704-79-7.gif)
112704-79-7
515 suppliers
$15.00/5 g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
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$15.00/10g
![Methyl 4-bromo-2-fluorobenzoate](/CAS/GIF/179232-29-2.gif)
179232-29-2
216 suppliers
$9.00/5g
![4-Bromo-2-fluorobenzoic acid](/CAS/GIF/112704-79-7.gif)
112704-79-7
515 suppliers
$15.00/5 g
![Methyl 4-bromo-2-fluorobenzoate](/CAS/GIF/179232-29-2.gif)
179232-29-2
216 suppliers
$9.00/5g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$7.29/5ml-f
![4-BROMO-2-FLUOROBENZOYL CHLORIDE](/CAS/GIF/151982-51-3.gif)
151982-51-3
144 suppliers
$9.00/250mg
![Methyl 4-bromo-2-fluorobenzoate](/CAS/GIF/179232-29-2.gif)
179232-29-2
216 suppliers
$9.00/5g